Background:
@EN One of the most probable pathogenesis of vitiligo is autoimmune. Systemic cortico-steroids suppress immunity and may arrest the progression of vitiligo and lead to repigmentation.
@ES Objective:
@EN We have assessed the clinical effect of a oral small oral dose of corticosteroid to minimize side effects in vitiligo patients.
@ES Methods:
@EN Thirty four patients(9;male, 25;female) with vitiligo were evaluated in this study. The patients took 7.5mg-20mg prednisolone initially for 2 months and then the dosage was tapered to half of the initial dose at the 3rd month and half of dose
of 3rd
month for the last 4th month. We compared the effect of treatment of vitiligo before and after the study by photographs. And side effects were assessed at 1, 2, 3, and 4 month
@ES Results:
@EN The arrest of the progression of vitiligo was noticed in 79% of patients and repigmentation was noticed in 59% of patients which is statistically significant, The effect of treatment according to extent, duration, type, and site of vitiligo
were not
statistically significant. The side effects of treatment were minimal and did not affect the course of treatment.
@ES Conclusion:
@EN Small doses of oral corticosteroids are effective without any significant side effects in preventing preventing progression and to induce repigmentation of active spreading vitiligo and generalized type of vitiligo that is difficult to treat
with
topical corticosteroids. (Kor J Dermatol 1995;33(5) :880~885)
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